Genomics

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SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia


ABSTRACT: We identified novel recurrent genetic lesions in T-PLL affecting genes involved in JAK/STAT signaling (PTPRC), epigenetic regulation (PRDM2), or DNA damage repair (SAMHD1, PARP10, HERC1, HERC2). Mutations of the tumor suppressor gene SAMHD1 causing amino-acid exchanges or protein truncations as well as copy number variations in SAMHD1 were seen in 20% of cases.

ORGANISM(S): Homo sapiens

PROVIDER: GSE100844 | GEO | 2018/07/23

REPOSITORIES: GEO

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