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Genome-wide mapping of Runx1-bound sites in early B-cell progenitors

ABSTRACT: The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investigated its normal role in murine B-cell development. Gene expression analysis and genome-wide Runx1-occupancy studies support the hypothesis that Runx1 reinforces the transcription factor network in B-cell progenitors governing early B-cell survival and development . ChIP-seq experiments were performed in the proB-cell line BMiFLT3(15-3), stably transduced with the transcription factor Runx1, to identify Runx1-bound sites in early B-cell progenitors.

ORGANISM(S): Mus musculus

SUBMITTER: Neele Kriebitzsch

PROVIDER: E-GEOD-45377 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Runx1 targets in early B-cell progenitors

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