Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Silvia Halim
PROVIDER: E-GEOD-45711 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bon Hélène H Wadhwa Karan K Schreiner Alexander A Osborne Michelle M Carroll Thomas T Ramos-Montoya Antonio A Ross-Adams Helen H Visser Matthieu M Hoffmann Ralf R Ahmed Ahmed Ashour AA Neal David E DE Mills Ian G IG
Molecular cancer research : MCR 20141229 4
<h4>Unlabelled</h4>Salt-inducible kinase 2 (SIK2) is a multifunctional kinase of the AMPK family that plays a role in CREB1-mediated gene transcription and was recently reported to have therapeutic potential in ovarian cancer. The expression of this kinase was investigated in prostate cancer clinical specimens. Interestingly, auto-antibodies against SIK2 were increased in the plasma of patients with aggressive disease. Examination of SIK2 in prostate cancer cells found that it functions both as ...[more]