Polysomes
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Daniel Hogan
PROVIDER: E-GEOD-45797 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes.
del Alamo Marta M Hogan Daniel J DJ Pechmann Sebastian S Albanese Veronique V Brown Patrick O PO Frydman Judith J
PLoS biology 20110712 7
Polypeptides exiting the ribosome must fold and assemble in the crowded environment of the cell. Chaperones and other protein homeostasis factors interact with newly translated polypeptides to facilitate their folding and correct localization. Despite the extensive efforts, little is known about the specificity of the chaperones and other factors that bind nascent polypeptides. To address this question we present an approach that systematically identifies cotranslational chaperone substrates thr ...[more]
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