Ontology highlight
ABSTRACT:
ORGANISM(S): Candida albicans
SUBMITTER: Sneh Panwar
PROVIDER: E-GEOD-46003 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Antimicrobial agents and chemotherapy 20130826 11
Mitochondrial dysfunction in Candida albicans is known to be associated with drug susceptibility, cell wall integrity, phospholipid homeostasis, and virulence. In this study, we deleted CaFZO1, a key component required during biogenesis of functional mitochondria. Cells with FZO1 deleted displayed fragmented mitochondria, mitochondrial genome loss, and reduced mitochondrial membrane potential and were rendered sensitive to azoles and peroxide. In order to understand the cellular response to dysf ...[more]