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Transcriptional profiling of orf19.5100/MLT1 ABC transporter knockout in Candida albicans

ABSTRACT: Recent reports have been suggested involvement of ABC transporters in various physiological roles.To get better insight about possible involvement of vacuolar ABC transporter MLT1/orf19.5100 in different physiological roles transcriptional profiling have been peformed and compared between WT(SC5314) Candida albicans cells vs putative orf19.5100 knockout cells after 6hrs growth of culture.The assay as peformed in biological duplicate sample. Agilent one-color experiment,Organism: Candida albicans ,Custom Agilent Candida albicans 8x15k Microarray Gene expression (AMADID: 026377) designed by Genotypic Technology Private Limited , Labeling kit: Agilent Quick-Amp labeling Kit (p/n5190-0442)

ORGANISM(S): Candida albicans

SUBMITTER: Nitesh Khandelwal

PROVIDER: E-GEOD-70341 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.

Khandelwal Nitesh Kumar NK Kaemmer Philipp P Förster Toni M TM Singh Ashutosh A Coste Alix T AT Andes David R DR Hube Bernhard B Sanglard Dominique D Chauhan Neeraj N Kaur Rupinder R d'Enfert Christophe C Mondal Alok Kumar AK Prasad Rajendra R

The Biochemical journal 20160329 11

Among the several mechanisms that contribute to MDR (multidrug resistance), the overexpression of drug-efflux pumps belonging to the ABC (ATP-binding cassette) superfamily is the most frequent cause of resistance to antifungal agents. The multidrug transporter proteins Cdr1p and Cdr2p of the ABCG subfamily are major players in the development of MDR in Candida albicans Because several genes coding for ABC proteins exist in the genome of C. albicans, but only Cdr1p and Cdr2p have established role ...[more]

PMID: 27026051

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