Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Christoffer Bro
PROVIDER: E-GEOD-461 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bro Christoffer C Regenberg Birgitte B Lagniel Gilles G Labarre Jean J Montero-Lomelí Mónica M Nielsen Jens J
The Journal of biological chemistry 20030605 34
Lithium is highly toxic to yeast when grown in galactose medium mainly because phosphoglucomutase, a key enzyme of galactose metabolism, is inhibited. We studied the global protein and gene expression profiles of Saccharomyces cerevisiae grown in galactose in different time intervals after addition of lithium. These results were related to physiological studies where both secreted and intracellular metabolites were determined. Microarray analysis showed that 664 open reading frames were down-reg ...[more]