Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Susan Chan
PROVIDER: E-GEOD-46114 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Geimer Le Lay Anne-Solen AS Oravecz Attila A Mastio Jérôme J Jung Claudia C Marchal Patricia P Ebel Claudine C Dembélé Doulaye D Jost Bernard B Le Gras Stéphanie S Thibault Christelle C Borggrefe Tilman T Kastner Philippe P Chan Susan S
Science signaling 20140318 317
The Notch signaling pathway is activated in many cell types, but its effects are cell type- and stage-specific. In the immune system, Notch activity is required for the differentiation of T cell progenitors, but it is reduced in more mature thymocytes, in which Notch is oncogenic. Studies based on single-gene models have suggested that the tumor suppressor protein Ikaros plays an important role in repressing the transcription of Notch target genes. We used genome-wide analyses, including chromat ...[more]