Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Irwin Davidson
PROVIDER: E-GEOD-57814 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Alpern Daniil D Langer Diana D Ballester Benoit B Le Gras Stephanie S Romier Christophe C Mengus Gabrielle G Davidson Irwin I
eLife 20140910
The functions of the TAF subunits of mammalian TFIID in physiological processes remain poorly characterised. In this study, we describe a novel function of TAFs in directing genomic occupancy of a transcriptional activator. Using liver-specific inactivation in mice, we show that the TAF4 subunit of TFIID is required for post-natal hepatocyte maturation. TAF4 promotes pre-initiation complex (PIC) formation at post-natal expressed liver function genes and down-regulates a subset of embryonic expre ...[more]