Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Joachim Schultze
PROVIDER: E-GEOD-46275 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ma Yuting Y Mattarollo Stephen R SR Adjemian Sandy S Yang Heng H Aymeric Laetitia L Hannani Dalil D Portela Catani João Paulo JP Duret Helene H Teng Michele W L MW Kepp Oliver O Wang Yidan Y Sistigu Antonella A Schultze Joachim L JL Stoll Gautier G Galluzzi Lorenzo L Zitvogel Laurence L Smyth Mark J MJ Kroemer Guido G
Cancer research 20131203 2
The therapeutic efficacy of anthracyclines relies, at least partially, on the induction of a dendritic cell- and T-lymphocyte-dependent anticancer immune response. Here, we show that anthracycline-based chemotherapy promotes the recruitment of functional CD11b(+)CD11c(+)Ly6C(high)Ly6G(-)MHCII(+) dendritic cell-like antigen-presenting cells (APC) into the tumor bed, but not into lymphoid organs. Accordingly, draining lymph nodes turned out to be dispensable for the proliferation of tumor antigen- ...[more]