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Genome-wide expression analysis of E18.5 and P30 olfactory bulbs of control and Tshz1 mutant mice

ABSTRACT: Analysis of genes regulated by Tshz1 in olfactory bulb neurons. Total RNA from olfactory bulbs of embryonic day E18.5 and postnatal day 30 control mice was compared to Tshz1 mutant mice

ORGANISM(S): Mus musculus

SUBMITTER: Hagen Wende

PROVIDER: E-GEOD-51761 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.

Ragancokova Daniela D Rocca Elena E Oonk Anne M M AM Schulz Herbert H Rohde Elvira E Bednarsch Jan J Feenstra Ilse I Pennings Ronald J E RJ Wende Hagen H Garratt Alistair N AN

The Journal of clinical investigation 20140301 3

The olfactory bulb (OB) receives odor information from the olfactory epithelium and relays this to the olfactory cortex. Using a mouse model, we found that development and maturation of OB interneurons depends on the zinc finger homeodomain factor teashirt zinc finger family member 1 (TSHZ1). In mice lacking TSHZ1, neuroblasts exhibited a normal tangential migration to the OB; however, upon arrival to the OB, the neuroblasts were distributed aberrantly within the radial dimension, and many immat ...[more]

PMID: 24487590

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