Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Michela Riba
PROVIDER: E-GEOD-46287 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Riba Michela M Rausa Marco M Sorosina Melissa M Cittaro Davide D Garcia Manteiga Jose Manuel JM Nai Antonella A Pagani Alessia A Martinelli-Boneschi Filippo F Stupka Elia E Camaschella Clara C Silvestri Laura L
PloS one 20130729 7
Control of systemic iron homeostasis is interconnected with the inflammatory response through the key iron regulator, the antimicrobial peptide hepcidin. We have previously shown that mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inflammatory response that is blunted in iron deficient-high hepcidin Tmprss6 KO mice. The transcriptional response associated with chronic hepcidin overexpression due to genetic inactivation of Tmprss6 is unknown. By using whole genome transcription pr ...[more]