Effect of ppGpp on Salmonella Typhimurium gene expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Salmonella typhimurium
SUBMITTER: Matthew Rolfe
PROVIDER: E-GEOD-4631 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The bacterial signal molecule, ppGpp, mediates the environmental regulation of both the invasion and intracellular virulence gene programs of Salmonella.
Thompson Arthur A Rolfe Matthew D MD Lucchini Sacha S Schwerk Peter P Hinton Jay C D JC Tedin Karsten K
The Journal of biological chemistry 20060811 40
During infection of mammalian hosts, facultative intracellular pathogens have to adjust rapidly to different environmental conditions encountered during passage through the gastrointestinal tract and following uptake into epithelial cells and macrophages. Successful establishment within the host therefore requires the coordinated expression of a large number of virulence genes necessary for the adaptation between the extracellular and intracellular phases of infection. In this study we show that ...[more]
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