Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Coxiella burnetii, the agent of Q fever, persists in adipocytes


ABSTRACT: Coxiella burnetii, the agent of Q fever, persists in humans despite specific immune responses: however, its reservoir remains unknown. We detected C. burnetii in adipose tissue from BALB/c and C57/BL6 mice 4 months after infection when no bacteria were found in other tissues. C. burnetii infected cultivated adipocytes, replicated within late phagosomes and induced a transcriptional program that was enriched for the expression of genes associated with inflammatory response, hormonal responses and cytoskeleton. 3T3-L1 (ATCC) differentiated adipocytes were stimulated or not with Coxiella burnetii (NMI) at a ratio of 50 bacteria per cell. Four biological replicates were analyzed in each group. Due to technical reason, one unstimulated sample was discarded from the analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Julien Textoris 

PROVIDER: E-GEOD-46335 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


Coxiella burnetii, the agent of Q fever, is known to persist in humans and rodents but its cellular reservoir in hosts remains undetermined. We hypothesized that adipose tissue serves as a C. burnetii reservoir during bacterial latency. BALB/c and C57BL/6 mice were infected with C. burnetii by the intraperitoneal route or the intracheal route. Adipose tissue was tested for the presence of C. burnetii several months after infection. C. burnetii was detected in abdominal, inguinal and dorsal adipo  ...[more]

Similar Datasets

2015-05-01 | E-GEOD-37666 | biostudies-arrayexpress
2016-03-13 | E-GEOD-66476 | biostudies-arrayexpress
2015-02-27 | E-GEOD-49016 | biostudies-arrayexpress
2011-01-01 | E-GEOD-21778 | biostudies-arrayexpress
2014-01-07 | E-GEOD-38747 | biostudies-arrayexpress
2011-12-31 | E-GEOD-31543 | biostudies-arrayexpress
2010-10-02 | E-GEOD-21065 | biostudies-arrayexpress
2014-05-25 | GSE46335 | GEO
2010-01-08 | E-GEOD-19757 | biostudies-arrayexpress
2011-01-01 | GSE21778 | GEO