Atrial Identity Is Determined by A COUP-TFII Regulatory Network
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: San-pin Wu
PROVIDER: E-GEOD-46498 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Atrial identity is determined by a COUP-TFII regulatory network.
Wu San-pin SP Cheng Chiang-Min CM Lanz Rainer B RB Wang Tiannan T Respress Jonathan L JL Ather Sameer S Chen Wen W Tsai Shaw-Jenq SJ Wehrens Xander H T XH Tsai Ming-Jer MJ Tsai Sophia Y SY
Developmental cell 20130501 4
Atria and ventricles exhibit distinct molecular profiles that produce structural and functional differences between the two cardiac compartments. However, the factors that determine these differences remain largely undefined. Cardiomyocyte-specific COUP-TFII ablation produces ventricularized atria that exhibit ventricle-like action potentials, increased cardiomyocyte size, and development of extensive T tubules. Changes in atrial characteristics are accompanied by alterations of 2,584 genes, of ...[more]
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Project description:Atria and ventricles exhibit distinct molecular profiles that produce structural and functional differences between the two cardiac compartments. However, factors that determine these differences remain largely undefined. Cardiomyocyte-specific COUP- TFII ablation produces ventricularized atria that exhibit ventricle-like action potentials, increased cardiomyocyte size, and development of extensive T-tubules. We used microarrays to examine the molecular profile of cardiomyocyte-specific COUP-TFII knockout adult atria in comparison with that of normal atria. We extracted RNA from mutant right atria, control right atria and control ventricles from 2 months old adult mice, followed by gene expression profiling using Affymetrix microarrays.
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