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Atrial Identity Is Determined by A COUP-TFII Regulatory Network (ChIP-Seq)

ABSTRACT: Embryonic cardiomyocytes possess the plasticity to choose between atrial and ventricular fates. For a limited window of time, the transcription factor COUP-TFII (Nr2f2) sufficiently and essentially confers the atrial identity through direct and indirect regulation of nearly half of chamber specific genes. Examination of COUP-TFII binding sites in embryonic artia

ORGANISM(S): Mus musculus

SUBMITTER: San-pin Wu

PROVIDER: E-GEOD-46497 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Atrial identity is determined by a COUP-TFII regulatory network.

Wu San-pin SP Cheng Chiang-Min CM Lanz Rainer B RB Wang Tiannan T Respress Jonathan L JL Ather Sameer S Chen Wen W Tsai Shaw-Jenq SJ Wehrens Xander H T XH Tsai Ming-Jer MJ Tsai Sophia Y SY

Developmental cell 20130501 4

Atria and ventricles exhibit distinct molecular profiles that produce structural and functional differences between the two cardiac compartments. However, the factors that determine these differences remain largely undefined. Cardiomyocyte-specific COUP-TFII ablation produces ventricularized atria that exhibit ventricle-like action potentials, increased cardiomyocyte size, and development of extensive T tubules. Changes in atrial characteristics are accompanied by alterations of 2,584 genes, of ...[more]

PMID: 23725765

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Genome-wide Profiling of NR2F2 (COUP-TFII) Binding in Human Endometrial Stromal Cells [ChIP-Seq]

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2013-11-02 | E-GEOD-52008 | biostudies-arrayexpress

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Project description:Embryonic cardiomyocytes possess the plasticity to choose between atrial and ventricular fates. For a limited window of time, the transcription factor COUP-TFII (Nr2f2) sufficiently and essentially confers the atrial identity through direct and indirect regulation of nearly half of chamber specific genes.

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Expression data from control and COUP-TFII siRNA treated HUVEC cells

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