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Yeast X-Chromosome Associated Protein 5 (Xap5) Functions with H2A.Z to Suppress Aberrant Transcripts [ChIP-chip]

ABSTRACT: Comparison of occupancy profiling of Xap5 and H2A.Z/Pht1 in fission yeast. Agilent 60mer array was used to analyze DNA recovered by chromatin immunoprecipitation of Xap5 from fission yeast culture.

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Shajahan Anver

PROVIDER: E-GEOD-46505 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver Shajahan S Roguev Assen A Zofall Martin M Krogan Nevan J NJ Grewal Shiv I S SI Harmer Stacey L SL

EMBO reports 20140623 8

Chromatin regulatory proteins affect diverse developmental and environmental response pathways via their influence on nuclear processes such as the regulation of gene expression. Through a genome-wide genetic screen, we implicate a novel protein called X-chromosome-associated protein 5 (Xap5) in chromatin regulation. We show that Xap5 is a chromatin-associated protein acting in a similar manner as the histone variant H2A.Z to suppress expression of antisense and repeat element transcripts throug ...[more]

PMID: 24957674

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