Ontology highlight
ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Shiv Grewal
PROVIDER: E-GEOD-32996 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Matsuda Emiko E Sugioka-Sugiyama Rie R Mizuguchi Takeshi T Mehta Sameet S Cui Bowen B Grewal Shiv I S SI
Proceedings of the National Academy of Sciences of the United States of America 20111031 46
Schizosaccharomyces pombe cells switch mating type by replacing genetic information at the expressed mat1 locus with sequences copied from mat2-P or mat3-M silent donor loci. The choice of donor locus is dictated by cell type, such that mat2 is the preferred donor in M cells and mat3 is the preferred donor in P cells. Donor choice involves a recombination-promoting complex (RPC) containing Swi2 and Swi5. In P cells, the RPC localizes to a specific DNA element located adjacent to mat3, but in M c ...[more]