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An SRY homolog cooperates with a transposon-derived CENP-B protein to control sex-specific directed recombination


ABSTRACT: Occupancy profiling of Myc tagged Mc protein in fission yeast. Agilent 60mer array was used to analyze DNA recovered by immunoprecipitation of Mc-myc protein from culture of fission yeast.

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Shiv Grewal 

PROVIDER: E-GEOD-32996 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A homolog of male sex-determining factor SRY cooperates with a transposon-derived CENP-B protein to control sex-specific directed recombination.

Matsuda Emiko E   Sugioka-Sugiyama Rie R   Mizuguchi Takeshi T   Mehta Sameet S   Cui Bowen B   Grewal Shiv I S SI  

Proceedings of the National Academy of Sciences of the United States of America 20111031 46


Schizosaccharomyces pombe cells switch mating type by replacing genetic information at the expressed mat1 locus with sequences copied from mat2-P or mat3-M silent donor loci. The choice of donor locus is dictated by cell type, such that mat2 is the preferred donor in M cells and mat3 is the preferred donor in P cells. Donor choice involves a recombination-promoting complex (RPC) containing Swi2 and Swi5. In P cells, the RPC localizes to a specific DNA element located adjacent to mat3, but in M c  ...[more]

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