Transcription profiling of developing human erythroid progenitor cells sampled at multiple time points reveals patterns of coregulation and potential transcriptional regulators.
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Sankar Addya
PROVIDER: E-GEOD-4655 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptional regulatory network analysis of developing human erythroid progenitors reveals patterns of coregulation and potential transcriptional regulators.
Keller M A MA Addya S S Vadigepalli R R Banini B B Delgrosso K K Huang H H Surrey S S
Physiological genomics 20060829 1
Deciphering the molecular basis for human erythropoiesis should yield information benefiting studies of the hemoglobinopathies and other erythroid disorders. We used an in vitro erythroid differentiation system to study the developing red blood cell transcriptome derived from adult CD34+ hematopoietic progenitor cells. mRNA expression profiling was used to characterize developing erythroid cells at six time points during differentiation (days 1, 3, 5, 7, 9, and 11). Eleven thousand seven hundred ...[more]
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