Ontology highlight
ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Geoffrey Neale
PROVIDER: E-GEOD-46649 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Creamer Kevin M KM Job Godwin G Shanker Sreenath S Neale Geoffrey A GA Lin Yuan-chi YC Bartholomew Blaine B Partridge Janet F JF
Molecular and cellular biology 20140324 11
Mit1 is the putative chromatin remodeling subunit of the fission yeast Snf2/histone deacetylase (HDAC) repressor complex (SHREC) and is known to repress transcription at regions of heterochromatin. However, how Mit1 modifies chromatin to silence transcription is largely unknown. Here we report that Mit1 mobilizes histone octamers in vitro and requires ATP hydrolysis and conserved chromatin tethering domains, including a previously unrecognized chromodomain, to remodel nucleosomes and silence tra ...[more]