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Affymetrix SNP array data for 29 MCL cases

ABSTRACT: DNA from four 29 cases, 38 tumor samples (23 PB, 12 LN, 1 Tonsil, 1 colonic biopsy, 1 spleen) and 29 normal DNA from the same patients were analyzed with Affymetrix SNP 6.0 platform for copy number alterations study. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from blood samples, lymph nodes and other tissues like spleen, tonsil and colonic biopsy Copy number analysis of Affymetrix SNP 6.0 arrays was performed for 29 MCL cases samples and their respective matched non-tumor DNA, which were used as references for copy number inference.

ORGANISM(S): Homo sapiens

SUBMITTER: Sílvia Beà 

PROVIDER: E-GEOD-46969 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.

Beà Sílvia S   Valdés-Mas Rafael R   Navarro Alba A   Salaverria Itziar I   Martín-Garcia David D   Jares Pedro P   Giné Eva E   Pinyol Magda M   Royo Cristina C   Nadeu Ferran F   Conde Laura L   Juan Manel M   Clot Guillem G   Vizán Pedro P   Di Croce Luciano L   Puente Diana A DA   López-Guerra Mónica M   Moros Alexandra A   Roue Gael G   Aymerich Marta M   Villamor Neus N   Colomo Lluís L   Martínez Antonio A   Valera Alexandra A   Martín-Subero José I JI   Amador Virginia V   Hernández Luis L   Rozman Maria M   Enjuanes Anna A   Forcada Pilar P   Muntañola Ana A   Hartmann Elena M EM   Calasanz María J MJ   Rosenwald Andreas A   Ott German G   Hernández-Rivas Jesús M JM   Klapper Wolfram W   Siebert Reiner R   Wiestner Adrian A   Wilson Wyndham H WH   Colomer Dolors D   López-Guillermo Armando A   López-Otín Carlos C   Puente Xose S XS   Campo Elías E  

Proceedings of the National Academy of Sciences of the United States of America 20131021 45

Mantle cell lymphoma (MCL) is an aggressive tumor, but a subset of patients may follow an indolent clinical course. To understand the mechanisms underlying this biological heterogeneity, we performed whole-genome and/or whole-exome sequencing on 29 MCL cases and their respective matched normal DNA, as well as 6 MCL cell lines. Recurrently mutated genes were investigated by targeted sequencing in an independent cohort of 172 MCL patients. We identified 25 significantly mutated genes, including kn  ...[more]

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