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A recurrent 11q aberration pattern characterizes a subset of MYC-negative mature aggressive B-cell lymphomas resembling Burkitt lymphoma

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Itziar Salaverria

PROVIDER: E-GEOD-47508 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma.

Salaverria Itziar I Martin-Guerrero Idoia I Wagener Rabea R Kreuz Markus M Kohler Christian W CW Richter Julia J Pienkowska-Grela Barbara B Adam Patrick P Burkhardt Birgit B Claviez Alexander A Damm-Welk Christine C Drexler Hans G HG Hummel Michael M Jaffe Elaine S ES Küppers Ralf R Lefebvre Christine C Lisfeld Jasmin J Löffler Markus M Macleod Roderick A F RA Nagel Inga I Oschlies Ilske I Rosolowski Maciej M Russell Robert B RB Russell Robert B RB Rymkiewicz Grzegorz G Schindler Detlev D Schlesner Matthias M Scholtysik René R Schwaenen Carsten C Spang Rainer R Szczepanowski Monika M Trümper Lorenz L Vater Inga I Wessendorf Swen S Klapper Wolfram W Siebert Reiner R

Blood 20140107 8

The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly called BL by 2 gene expression classifiers among 753 B-cell lymphomas. Only 2 (3%) of these 59 molecular BL lacked a MYC translocation, which both shared a peculiar pattern of chromosome 11q aberration characterized by interstitial gains including 1 ...[more]

PMID: 24398325

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