Unknown,Transcriptomics,Genomics,Proteomics

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Profiling of hepatic progenitor cells isolated from Egfr fl/fl and Met fl/fl murine control livers


ABSTRACT: Transcriptomic profiling; Determination of the transcriptomic similarity between Egfr fl/fl and Met fl/fl progenitor cells isolated from excised livers (n=3, each) Profiling of hepatic progenitor cells

ORGANISM(S): Mus musculus

SUBMITTER: Jesper Andersen 

PROVIDER: E-GEOD-46981 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


The relative contribution of hepatocyte growth factor (HGF)/MET and epidermal growth factor (EGF)/EGF receptor (EGFR), two key signal transduction systems in the normal and diseased liver, to fate decisions of adult hepatic progenitor cells (HPCs) has not been resolved. Here, we developed a robust culture system that permitted expansion and genetic manipulation of cells capable of multilineage differentiation in vitro and in vivo to examine the individual roles of HGF/MET and EGF/EGFR in HPC sel  ...[more]

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