Unknown,Transcriptomics,Genomics,Proteomics

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SMN MO, Gemin2 MO knockdown vs Control MO injected


ABSTRACT: Transcriptiome profiling of SMN MO injected, Gemin2 MO injected zebrafish embryos vs Control MO injected Two condition experiment : MO injected vs control. Biological replicates for SMN MO injected : 6, Biological replicates for Gemin2 MO injected: 7; Control MO injected from 6 independent batches pooled to serve as common control sample in all arrays.

ORGANISM(S): Danio rerio

SUBMITTER: Kelvin See 

PROVIDER: E-GEOD-47001 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy.

See Kelvin K   Yadav Preeti P   Giegerich Marieke M   Cheong Pearl S PS   Graf Martin M   Vyas Himanshu H   Lee Serene G P SG   Mathavan Sinnakaruppan S   Fischer Utz U   Sendtner Michael M   Winkler Christoph C  

Human molecular genetics 20131111 7


Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease affecting lower motor neurons. SMA is caused by mutations in the Survival Motor Neuron 1 (SMN1) gene, which result in reduced levels of functional SMN protein. Biochemical studies have linked the ubiquitously expressed SMN protein to the assembly of pre-mRNA processing U snRNPs, raising the possibility that aberrant splicing is a major defect in SMA. Accordingly, several transcripts affected upon SMN deficiency have been re  ...[more]

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