Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Impaired Transcriptional Response of the Murine Heart To Cigarette Smoke in the Setting of High Fat Diet and Obesity


ABSTRACT: To identify biosignatures that describe these lifestyle susceptibility factors, we performed parallel exposures of regular weight (RW) C57BL/6 and diet-induced obese (DIO) C57BL/6 mice to cigarette smoke, either mainstream (MS) or sidestream (SS), mimicking both the smoker and environmental exposure through second-hand smoke, respectively. Transcriptional responses were measured by global microarray analysis of heart tissue. Groups (N=6-8 biological replicates) of RW and DIO C57BL/6 mice (15-weeks old at start of exposures) were exposed to either filtered air (sham controls, SC), mainstream (MS) or sidestream (SS) cigarette smoke by nose-only inhalation exposure for 5 hr/day for a total of eight exposures over two weeks as follows: 5 consecutive days of exposure, followed by 2 days with no exposure, then three days of exposure, with necropsies occurring the day following the last exposure.

ORGANISM(S): Mus musculus

SUBMITTER: Susan Tilton 

PROVIDER: E-GEOD-47022 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2012-09-15 | E-GEOD-38093 | biostudies-arrayexpress
2012-09-15 | E-GEOD-38092 | biostudies-arrayexpress
2012-01-01 | E-GEOD-28804 | biostudies-arrayexpress
2013-04-22 | E-GEOD-45892 | biostudies-arrayexpress
2010-03-08 | E-GEOD-18858 | biostudies-arrayexpress
2012-09-15 | GSE38093 | GEO
2013-05-17 | GSE47022 | GEO
2021-03-18 | E-MTAB-9597 | biostudies-arrayexpress
2009-09-18 | E-GEOD-17933 | biostudies-arrayexpress
2009-04-23 | E-GEOD-5128 | biostudies-arrayexpress