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Expression data from wild type and Gata6-deficient tissue resident peritoneal macrophages

ABSTRACT: Tissue resident macrophages are notoriously heterogeneous, exhibiting discrete phenotypes as a consequence of tissue- and micro-anatomical niche-specific functions, but the molecular basis for this is not understood. We resolved a restricted transcriptional profile for the self-renewing population of peritoneal resident macrophages, which is expressed during homeostasis and inflammation and distinct from other MM-CM-^X. Prominent within this profile was the expression of Gata6. This study represents a characterisation of the role of Gata6 in peritoneal resident macrophage phenotype. We used microarrays to determine the patterns of gene expression in peritoneal resident MM-CM-^X in the absence of GATA-6 against wild type. Conditional 'floxed' Gata6 deficient sex-matched mice between 7 weeks old were compared against wild type

ORGANISM(S): Mus musculus

SUBMITTER: Timothy Stone

PROVIDER: E-GEOD-47049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Rosas Marcela M Davies Luke C LC Giles Peter J PJ Liao Chia-Te CT Kharfan Bashar B Stone Timothy C TC O'Donnell Valerie B VB Fraser Donald J DJ Jones Simon A SA Taylor Philip R PR

Science (New York, N.Y.) 20140424 6184

Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche-specific functions. Many populations self-renew independently of bone marrow in the adult, but the molecular mechanisms of this are poorly understood. We determined a transcriptional profile for the major self-renewing population of peritoneal macrophages in mice. These cells specifically expressed the transcription factor Gata6. Selective deficiency of Gata6 in myeloid cells caused substantial alterations in the ...[more]

PMID: 24762537

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microRNA transcriptome data from wild type and Gata6-deficient tissue resident peritoneal macrophages

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Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

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microRNA transcriptome data from wild type and Gata6-deficient tissue resident peritoneal macrophages

Project description:microRNA transcriptome data from wild type and Gata6-deficient tissue resident peritoneal macrophages

| PRJEB62866 | ENA

RNA-seq gene expression profiles of primary murine peritoneal mesothelial cells.

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