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MicroRNA transcriptome data from wild type and Gata6-deficient tissue resident peritoneal macrophages

ABSTRACT: microRNA transcriptome data from wild type and Gata6-deficient tissue resident peritoneal macrophages

PROVIDER: PRJEB62866 | ENA |

REPOSITORIES: ENA

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microRNA transcriptome data from wild type and Gata6-deficient tissue resident peritoneal macrophages

Project description:microRNA transcriptome data from wild type and Gata6-deficient tissue resident peritoneal macrophages. Tissue resident macrophages are notoriously heterogeneous, exhibiting discrete phenotypes as a consequence of tissue- and micro-anatomical niche-specific functions, but the molecular basis for this is not understood. Gata6 itself has been shown to be a target of multiple miR. However, microRNA transcriptome and its dependence on tissue-specific macrophage programming, such as effected by GATA6, has not been explored. We used microRNA sequencing to determine the patterns of microRNA expression in peritoneal resident macrophages at homeostasis in the absence of GATA-6 against wild type.

2023-06-30 | E-MTAB-13039 | biostudies-arrayexpress

Expression data from wild type and Gata6-deficient tissue resident peritoneal macrophages

Project description:Tissue resident macrophages are notoriously heterogeneous, exhibiting discrete phenotypes as a consequence of tissue- and micro-anatomical niche-specific functions, but the molecular basis for this is not understood. We resolved a restricted transcriptional profile for the self-renewing population of peritoneal resident macrophages, which is expressed during homeostasis and inflammation and distinct from other MM-CM-^X. Prominent within this profile was the expression of Gata6. This study represents a characterisation of the role of Gata6 in peritoneal resident macrophage phenotype. We used microarrays to determine the patterns of gene expression in peritoneal resident MM-CM-^X in the absence of GATA-6 against wild type. Conditional 'floxed' Gata6 deficient sex-matched mice between 7 weeks old were compared against wild type

2014-05-09 | E-GEOD-47049 | biostudies-arrayexpress

Expression data from wild type and Gata6-deficient tissue resident peritoneal macrophages

Project description:Tissue resident macrophages are notoriously heterogeneous, exhibiting discrete phenotypes as a consequence of tissue- and micro-anatomical niche-specific functions, but the molecular basis for this is not understood. We resolved a restricted transcriptional profile for the self-renewing population of peritoneal resident macrophages, which is expressed during homeostasis and inflammation and distinct from other MØ. Prominent within this profile was the expression of Gata6. This study represents a characterisation of the role of Gata6 in peritoneal resident macrophage phenotype. We used microarrays to determine the patterns of gene expression in peritoneal resident MØ in the absence of GATA-6 against wild type.

2014-05-09 | GSE47049 | GEO

GATA6 dependent gene regulation in peritoneal macrophages

Project description:Peritoneal macrophages from control and Mac-Gata6 KO (LysM-cre;Gata6-floxed) mice were determined for genome wide gene expression. Sorted peritoneal macrophages from control and Mac-Gata6 KO mice were performed for whole genome expression analysis by Illumina microarray

2014-05-02 | E-GEOD-56684 | biostudies-arrayexpress

GATA6 dependent gene regulation in peritoneal macrophages

Project description:Peritoneal macrophages from control and Mac-Gata6 KO (LysM-cre;Gata6-floxed) mice were determined for genome wide gene expression.

2014-05-02 | GSE56684 | GEO

Gene expression in CD163-deficient resident macrophages

Project description:To investigate CD163-related signals and cytokine production, mRNA expression of resident peritoneal marophages derived from wild type mice and CD163-deficient mice was analyzed.

2021-03-01 | GSE111679 | GEO

RNA transcriptome data from C57BL/6 tissue resident peritoneal macrophages over expressing microRNA 708 or control

Project description:RNA transcriptome data from C57BL/6 tissue resident peritoneal macrophages over expressing microRNA 708 or control. The role of microRNA-708 in shaping macrophage biology remains mostly unknown. Here, using lentiviral vectors we overexpressed microRNA-708 in vivo in C57BL/6 mice peritoneal macrophages and investigated mRNA changes in these cells after 4 days.

2024-05-03 | E-MTAB-13782 | biostudies-arrayexpress

Cultured resident and thioglycolate-elicited mouse peritoneal macrophages

Project description:In macrophage biology, resident peritoneal macrophages (RPMs) and thioglycolate-elicited peritoneal macrophages (TGPMs) have been traditionally utilized as primary cultured models. RPMs and TGPMs display distinct morphological and functional characteristics. We analyzed altered gene expression between RPMs from control mice and TGPMs from thioglycolate-injected mice.

2020-10-07 | GSE159119 | GEO

Cultured resident and thioglycolate-elicited mouse peritoneal macrophages

Project description:Cultured resident and thioglycolate-elicited mouse peritoneal macrophages

| PRJNA667718 | ENA

Expression profile of GATA6 deficient pancreatic islets

Project description:GATA6 mutations have been linked to adult-onset diabetes with subclinical or no exocrine insufficiency suggesting an important role for GATA6 in humanβcell physiology. To investigate the role of GATA6 in adult endocrine pancreas, we generated mice in which Gata6 is specifically inactivated in the pancreas. These mice develop glucose intolerance. Islets deficient in GATA6 activity display decreased insulin content and impaired glucose-induced insulin secretion. Gata6-deficient ß cells exhibit ultrastructural abnormalities including increased immature insulin granules, swollen mitochondria and disorganized endoplasmic reticulum. Microarray analysis revealed that loss of GATA6 greatly impacts ß cell specific gene expression.

2019-10-31 | GSE106316 | GEO

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