Identification of Oct4-dependent genes in vivo
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Paul Robson
PROVIDER: E-GEOD-47089 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst.
Frum Tristan T Halbisen Michael A MA Wang Chaoyang C Amiri Hossein H Robson Paul P Ralston Amy A
Developmental cell 20130606 6
In embryonic stem (ES) cells and in early mouse embryos, the transcription factor Oct4 is an essential regulator of pluripotency. Oct4 transcriptional targets have been described in ES cell lines; however, the molecular mechanisms by which Oct4 regulates establishment of pluripotency in the epiblast (EPI) have not been fully elucidated. Here, we show that neither maternal nor zygotic Oct4 is required for the formation of EPI cells in the blastocyst. Rather, Oct4 is first required for development ...[more]
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