Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Pogonomyrmex
TISSUE(S): Venom
SUBMITTER: Vanessa Schendel
LAB HEAD: Samuel D. Robinson
PROVIDER: PXD043773 | Pride | 2024-06-16
REPOSITORIES: Pride
Robinson Samuel D SD Deuis Jennifer R JR Niu Pancong P Touchard Axel A Mueller Alexander A Schendel Vanessa V Brinkwirth Nina N King Glenn F GF Vetter Irina I Schmidt Justin O JO
The Journal of biological chemistry 20231216 1
Harvester ants (genus Pogonomyrmex) are renowned for their stings which cause intense, long-lasting pain, and other neurotoxic symptoms in vertebrates. Here, we show that harvester ant venoms are relatively simple and composed largely of peptide toxins. One class of peptides is primarily responsible for the long-lasting local pain of envenomation via activation of peripheral sensory neurons. These hydrophobic, cysteine-free peptides potently modulate mammalian voltage-gated sodium (Na<sub>V</sub ...[more]