Unknown,Transcriptomics,Genomics,Proteomics

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MeDIP of adult whole brain tissue from fetal alcohol exposed mice


ABSTRACT: In this report we assessed alterations to adult mouse brain tissue by assaying DNA cytosine methylation and small noncoding RNA (ncRNA) expression, specifically the microRNA (miRNA) and small nucleolar RNA (snoRNA) subtypes. We found long lasting alterations in DNA methylation as a result of fetal alcohol exposure, specifically in the imprinted regions of the genome harboring ncRNAs and sequences interacting with regulatory proteins. ~20% of the altered ncRNAs mapped to three imprinted regions: Snrpn-Ube3a, Dlk1-Dio3, and Sfmbt2, which showed differential methylation and have been previously implicated in neurodevelopmental disorders. The findings of this report help to expand on the mechanisms behind the long lasting changes in the brain transcriptome of FASD individuals. Comparison of fetal alcohol exposed and matched control adult C57/BL6J mice brains with olfactory bulbs removed

ORGANISM(S): Mus musculus

SUBMITTER: Benjamin Laufer 

PROVIDER: E-GEOD-47111 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice.

Laufer Benjamin I BI   Mantha Katarzyna K   Kleiber Morgan L ML   Diehl Eric J EJ   Addison Sean M F SM   Singh Shiva M SM  

Disease models & mechanisms 20130410 4


Fetal alcohol spectrum disorders (FASDs) are characterized by life-long changes in gene expression, neurodevelopment and behavior. What mechanisms initiate and maintain these changes are not known, but current research suggests a role for alcohol-induced epigenetic changes. In this study we assessed alterations to adult mouse brain tissue by assaying DNA cytosine methylation and small noncoding RNA (ncRNA) expression, specifically the microRNA (miRNA) and small nucleolar RNA (snoRNA) subtypes. W  ...[more]

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