Unknown,Transcriptomics,Genomics,Proteomics

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CHD chromatin remodelers regulate separate gene sets and distinct stages of Dictyostelium development


ABSTRACT: We utilized RNA-seq to profile expression levels in wild type AX2 cells and three mutants for the CHD family of ATP-dependent chromatin remodellers in Dictyostelium discoideum. Total RNA was polyA enriched and sequenced at two stages of development: in the growth stage (0H) and in 5H cAMP pulsed cells (5H). All mutants analysed were also in the AX2 background. Looking at mRNA levels in AX2, chdA-, chdB- and chdC-.

ORGANISM(S): Dictyostelium discoideum

SUBMITTER: James Plattt 

PROVIDER: E-GEOD-47222 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Different CHD chromatin remodelers are required for expression of distinct gene sets and specific stages during development of Dictyostelium discoideum.

Platt James L JL   Rogers Benjamin J BJ   Rogers Kelley C KC   Harwood Adrian J AJ   Kimmel Alan R AR  

Development (Cambridge, England) 20131201 24


Control of chromatin structure is crucial for multicellular development and regulation of cell differentiation. The CHD (chromodomain-helicase-DNA binding) protein family is one of the major ATP-dependent, chromatin remodeling factors that regulate nucleosome positioning and access of transcription factors and RNA polymerase to the eukaryotic genome. There are three mammalian CHD subfamilies and their impaired functions are associated with several human diseases. Here, we identify three CHD orth  ...[more]

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