Ontology highlight
ABSTRACT:
ORGANISM(S): Dictyostelium discoideum
SUBMITTER: James Plattt
PROVIDER: E-GEOD-47222 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Platt James L JL Rogers Benjamin J BJ Rogers Kelley C KC Harwood Adrian J AJ Kimmel Alan R AR
Development (Cambridge, England) 20131201 24
Control of chromatin structure is crucial for multicellular development and regulation of cell differentiation. The CHD (chromodomain-helicase-DNA binding) protein family is one of the major ATP-dependent, chromatin remodeling factors that regulate nucleosome positioning and access of transcription factors and RNA polymerase to the eukaryotic genome. There are three mammalian CHD subfamilies and their impaired functions are associated with several human diseases. Here, we identify three CHD orth ...[more]