Ontology highlight
ABSTRACT:
ORGANISM(S): Dictyostelium discoideum
SUBMITTER: Gareth Bloomfield
PROVIDER: E-TABM-1090 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Developmental biology 20110321 2
Dictyostelium is the only non-metazoan with functionally analyzed SH2 domains and studying them can give insights into their evolution and wider potential. LrrB has a novel domain configuration with leucine-rich repeat, 14-3-3 and SH2 protein-protein interaction modules. It is required for the correct expression of several specific genes in early development and here we characterize its role in later, multicellular development. During development in the light, slug formation in LrrB null (lrrB-) ...[more]