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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human skeletal muscle from obese vs.normal individuals to identify the mRNA of proteins involved in fat oxidation that may be reduced in obese and morbidly obese individuals

ABSTRACT: It has been found that fat oxidation is reduced in the skeletal muscle of obese humans. This study aims to identify the mRNA of proteins involved in fat oxidation that may be reduced in obese and morbidly obese individuals. Information gathered will help in understanding how obesity contributes to cardiovascular disease via insulin resistance. Samples were obtained from patients undergoing elective abdominal surgery.

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Hoffman

PROVIDER: E-GEOD-474 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle.

Park Jung-Jun JJ Berggren Jason R JR Hulver Matthew W MW Houmard Joseph A JA Hoffman Eric P EP

Physiological genomics 20060718 2

Obesity is associated with insulin resistance in skeletal muscle; accordingly, weight loss dramatically improves insulin action. We sought to identify molecular remodeling of muscle commensurate with weight loss that could explain improvements in insulin action. Muscle from morbidly obese women was studied before and after gastric bypass surgery. Gastric bypass surgery significantly reduced body mass by approximately 45% and improved insulin action. We then assessed mRNA profiles using a stringe ...[more]

PMID: 16849634

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