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Microarray analysis of CD9high and CD9low progenitors isolated from omental adipose tissue of morbid obese individuals

ABSTRACT: Obesity-induced white adipose tissue (WAT) fibrosis is believed to accelerate WAT dysfunction. Two progenitor populations could be distinguished in omental white adipose tissue (oWAT) of morbidly obese individuals based on CD9 expression. In addition, the frequency of CD9high progenitors in oWAT correlates with oWAT fibrosis level, insulin-resistance severity and type 2 diabetes. To further gain insight into the functional differences between the CD9high and CD9low progenitor subsets, we performed transcriptomic profiling of FACS-sorted progenitor populations isolated from oWAT of obese individuals. As CD9low progenitors were markedly decreased in glucose-intolerant or diabetic individuals, we investigated seven women with morbid obesity but without diabetes or glucose intolerance, according to the ADA definition.

ORGANISM(S): Homo sapiens

PROVIDER: GSE84821 | GEO | 2017/03/28

SECONDARY ACCESSION(S): PRJNA331208

REPOSITORIES: GEO

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