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Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Donny Licatalosi

PROVIDER: E-GEOD-47567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.

Licatalosi Donny D DD Yano Masato M Fak John J JJ Mele Aldo A Grabinski Sarah E SE Zhang Chaolin C Darnell Robert B RB

Genes & development 20120701 14

Two polypyrimidine tract RNA-binding proteins (PTBs), one near-ubiquitously expressed (Ptbp1) and another highly tissue-restricted (Ptbp2), regulate RNA in interrelated but incompletely understood ways. Ptbp1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by Ptbp2. To define the roles of Ptbp2 in the nervous system, we generated two independent Ptbp2-null strains, unexpectedly revealing that Ptbp2 is expressed in neuronal progenitors and is essential for p ...[more]

PMID: 22802532

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