Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse Peyers patch and mesenteric lymph nodes after oral infection with Y. enterolitica

ABSTRACT: To gain a comprehensive view of the host response to pathogens within these tissues, we determined the transcriptional profiles of intestinal lymphatic tissue infected with Y. enterocolitica. Expression analysis using Affymetrix GeneChips revealed a complex host response in the Peyer’s patches (PP) and mesenteric lymph nodes (MLN) following oral infection with Y. enterocolitica. Peyer's patches and mesenteric lymph nodes were surgically removed from uninfected (control) and infected (experimental) mice at 12 hours, day 2, 4 and 7 post oral infection. Tissue samples from 10 mice per time-point were combined. Total RNA was extracted using the Trizol method prior to total cDNA syntesis, labeling and hybridization to Affymetrix MGU74Av2 GeneChips. Data was processed and analyzed using MAS 5.0 and custom analysis protocols. Samples from Peyer's patches and mesenteric lymph nodes are included in this series.

ORGANISM(S): Mus musculus

DISEASE(S): Yersinia enterocolitica uninfected

SUBMITTER: Scott Allyn Handley 

PROVIDER: E-GEOD-4764 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Histamine signaling through the H(2) receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection.

Handley Scott A SA   Dube Peter H PH   Miller Virginia L VL  

Proceedings of the National Academy of Sciences of the United States of America 20060522 24

Enteric pathogens such as Yersinia enterocolitica readily colonize and induce disease within the lymphatic tissues of the small intestine. To gain a comprehensive view of the host response to pathogens within these tissues, we determined the transcriptional profiles of intestinal lymphatic tissue infected with Y. enterocolitica. Expression analysis using Affymetrix GeneChips revealed a complex host response in the Peyer's patches and mesenteric lymph nodes after oral infection with Y. enterocoli  ...[more]

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