Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: david irvine
PROVIDER: E-GEOD-47927 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood 20130708 7
Homologous recombination repair (HRR) protects cells from the lethal effect of spontaneous and therapy-induced DNA double-stand breaks. HRR usually depends on BRCA1/2-RAD51, and RAD52-RAD51 serves as back-up. To target HRR in tumor cells, a phenomenon called "synthetic lethality" was applied, which relies on the addiction of cancer cells to a single DNA repair pathway, whereas normal cells operate 2 or more mechanisms. Using mutagenesis and a peptide aptamer approach, we pinpointed phenylalanine ...[more]