Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiles of Siglec-14/THP-1 and Siglec-5/THP cell lines, with or without NTHi stimulation

ABSTRACT: Acquisition of a new strain of non-typeable Haemophilus influenzae (NTHi) is often associated with exacerbation of chronic obstructive pulmonary disease (COPD). We have previously reported that COPD patients who are homozygous null for SIGLEC14 gene is less susceptible to COPD exacerbation than those who have wild-type allele with functional SIGLEC14 gene. In order to gain insight into the mechanism behind the COPD exacerbation, and to find new clues that may lead to the discovery of objective biomarker of COPD exacerbation, Siglec-14/THP-1 and Siglec-5/THP-1 cell lines, which mimic monocytes from homozygous wild-type and homozygous SIGLEC14-null person, respectively, were incubated with or without NTHi, and their gene expression profiles were compared by using Affymetrix Human Genome U133 Plus 2.0 Array. Four samples (2 cell lines x 2 conditions) were analyzed. No replicates were made.

ORGANISM(S): Homo sapiens

SUBMITTER: Takashi Angata 

PROVIDER: E-GEOD-47929 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Association of serum interleukin-27 with the exacerbation of chronic obstructive pulmonary disease.

Angata Takashi T   Ishii Takeo T   Gao Congxiao C   Ohtsubo Kazuaki K   Kitazume Shinobu S   Gemma Akihiko A   Kida Kozui K   Taniguchi Naoyuki N  

Physiological reports 20140703 7

We have previously demonstrated that chronic obstructive pulmonary disease (COPD) patients who do not have Siglec-14 are less prone to exacerbation of the disease. Siglec-14 is a myeloid cell protein that recognizes bacteria and triggers inflammatory responses. Therefore, soluble mediators secreted by myeloid cells responding to Siglec-14 engagement could be involved in the pathogenesis of exacerbation and could potentially be utilized as biomarkers of exacerbation. To find out, we sought genes  ...[more]

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