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PSN1 Polysome and INK128

ABSTRACT: Polysome-bound mRNA was analyzed to determine the effects of INK128 and radiation on mRNA translation 4 samples were analyzed with 3 biological replicates

ORGANISM(S): Homo sapiens

SUBMITTER: Philip Tofilon

PROVIDER: E-GEOD-48098 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells.

Hayman Thomas J TJ Wahba Amy A Rath Barbara H BH Bae Heekyong H Kramp Tamalee T Shankavaram Uma T UT Camphausen Kevin K Tofilon Philip J PJ

Clinical cancer research : an official journal of the American Association for Cancer Research 20131106 1

<h4>Purpose</h4>Radiotherapy remains a primary treatment modality for pancreatic carcinoma, a tumor characterized by aberrant mTOR activity. Given the regulatory role of mTOR in gene translation, in this study, we defined the effects of the clinically relevant, ATP-competitive mTOR inhibitor, INK128 on the radiosensitivity of pancreatic carcinoma cell lines.<h4>Experimental design</h4>Clonogenic survival was used to determine the effects of INK128 on in vitro radiosensitivity of three pancreatic ...[more]

PMID: 24198241

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