Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Alexa Vitins
PROVIDER: E-GEOD-48126 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Vitins Alexa P AP Kienhuis Anne S AS Speksnijder Ewoud N EN Roodbergen Marianne M Luijten Mirjam M van der Ven Leo T M LT
Archives of toxicology 20140218 8
Liver injury is the leading cause of drug-induced toxicity. For the evaluation of a chemical compound to induce toxicity, in this case steatosis or fatty liver, it is imperative to identify markers reflective of mechanisms and processes induced upon exposure, as these will be the earliest changes reflective of disease. Therefore, an in vivo mouse toxicogenomics study was completed to identify common pathways, nuclear receptor (NR) binding sites, and genes regulated by three known human steatosis ...[more]