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Gene expression profiles of acetaminophen, isoniazid, and paraquat treated C57BL/6 mice

ABSTRACT: Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of necrosis in C57BL/6 mice treated by oral gavage using acetaminophen (APAP), isoniazid (INZ), and paraquat (PQ). Critical doses for tgx analysis were derived from a 25 day dose range finding study. For tgx analysis, livers of mice were collected 1 and 2 days after a single compound dose of 168.75, 225, and 300 mg/kg bw for APAP; 12.5, 25, and 50 mg/kg bw for PQ; and 22, 44, and 88 mg/kg bw for INZ. All samples were diluted in water.

ORGANISM(S): Mus musculus

PROVIDER: GSE51969 | GEO | 2014/12/16

SECONDARY ACCESSION(S): PRJNA225947

REPOSITORIES: GEO

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Gene expression profiles of acetaminophen, isoniazid, and paraquat treated C57BL/6 mice

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