Dendritic cell subtypes from lymph nodes and blood show contrasted gene expression programs upon Bluetongue Virus infection
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ABSTRACT:
ORGANISM(S): Ovis aries
SUBMITTER: Jouneau Luc
PROVIDER: E-GEOD-48450 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dendritic cell subtypes from lymph nodes and blood show contrasted gene expression programs upon Bluetongue virus infection.
Ruscanu Suzana S Jouneau Luc L Urien Céline C Bourge Mickael M Lecardonnel Jérôme J Moroldo Marco M Loup Benoit B Dalod Marc M Elhmouzi-Younes Jamila J Bevilacqua Claudia C Hope Jayne J Vitour Damien D Zientara Stéphan S Meyer Gilles G Schwartz-Cornil Isabelle I
Journal of virology 20130619 16
Human and animal hemorrhagic viruses initially target dendritic cells (DCs). It has been proposed, but not documented, that both plasmacytoid DCs (pDCs) and conventional DCs (cDCs) may participate in the cytokine storm encountered in these infections. In order to evaluate the contribution of DCs in hemorrhagic virus pathogenesis, we performed a genome-wide expression analysis during infection by Bluetongue virus (BTV), a double-stranded RNA virus that induces hemorrhagic fever in sheep and initi ...[more]
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