Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Tetsuya Nosaka
PROVIDER: E-GEOD-48539 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood 20130709 7
Oncogenic transformation requires unlimited self-renewal. Currently, it remains unclear whether a normal capacity for self-renewal is required for acquiring an aberrant self-renewal capacity. Our results in a new conditional transgenic mouse showed that a mixed lineage leukemia (MLL) fusion oncogene, MLL-ENL, at an endogenous-like expression level led to leukemic transformation selectively in a restricted subpopulation of hematopoietic stem cells (HSCs) through upregulation of promyelocytic leuk ...[more]