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In vivo T-box Transcription Factor Profiling Reveals Joint Regulation of Embryonic Neuro-mesodermal Bipotency.

ABSTRACT: We defined genome-wide regulatory inputs of the T-box transcription factors Brachyury (Xbra), Eomesodermin (Eomes) and VegT that maintain neuro-mesodermal stem cells and determine their bipotential fates in the Xenopus tropicalis frog embryo. Binding profiles for Xbra, Eomes and VegT in X. tropicalis embryos (ChIP-Seq)

ORGANISM(S): Xenopus (Silurana) tropicalis

SUBMITTER: George Gentsch

PROVIDER: E-GEOD-48560 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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In vivo T-box transcription factor profiling reveals joint regulation of embryonic neuromesodermal bipotency.

Gentsch George E GE Owens Nick D L ND Martin Stephen R SR Piccinelli Paul P Faial Tiago T Trotter Matthew W B MW Gilchrist Michael J MJ Smith James C JC

Cell reports 20130919 6

The design of effective cell replacement therapies requires detailed knowledge of how embryonic stem cells form primary tissues, such as mesoderm or neurectoderm that later become skeletal muscle or nervous system. Members of the T-box transcription factor family are key in the formation of these primary tissues, but their underlying molecular activities are poorly understood. Here, we define in vivo genome-wide regulatory inputs of the T-box proteins Brachyury, Eomesodermin, and VegT, which tog ...[more]

PMID: 24055059

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