Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jonghwan Kim
PROVIDER: E-GEOD-48666 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Beck Samuel S Lee Bum-Kyu BK Rhee Catherine C Song Jawon J Woo Andrew J AJ Kim Jonghwan J
Nature communications 20141118
Both transcriptional and epigenetic regulations are fundamental for the control of eukaryotic gene expression. Here we perform a compendium analysis of >200 large sequencing data sets to elucidate the regulatory logic of global gene expression programs in mouse embryonic stem (ES) cells. We define four major classes of DNA-binding proteins (Core, PRC, MYC and CTCF) based on their target co-occupancy, and discover reciprocal regulation between the MYC and PRC classes for the activity of nearly al ...[more]