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B lymphoma from TRAF3-deficient mice

ABSTRACT: Spleen samples with B lymphoma from TRAF3 knockout mice compared with littermate controls 3 lymphoma samples, 4 control samples

ORGANISM(S): Mus musculus

SUBMITTER: Ronald Hart

PROVIDER: E-GEOD-48818 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes.

Edwards Shanique K E SK Baron Jacqueline J Moore Carissa R CR Liu Yan Y Perlman David H DH Hart Ronald P RP Xie Ping P

Journal of hematology & oncology 20140909

<h4>Background</h4>Identification of novel genetic risk factors is imperative for a better understanding of B lymphomagenesis and for the development of novel therapeutic strategies. TRAF3, a critical regulator of B cell survival, was recently recognized as a tumor suppressor gene in B lymphocytes. The present study aimed to identify novel oncogenes involved in malignant transformation of TRAF3-deficient B cells.<h4>Methods</h4>We used microarray analysis to identify genes differentially express ...[more]

PMID: 25200342

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