Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Suzana Hadjur
PROVIDER: E-GEOD-48938 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Sofueva Sevil S Yaffe Eitan E Chan Wen-Ching WC Georgopoulou Dimitra D Vietri Rudan Matteo M Mira-Bontenbal Hegias H Pollard Steven M SM Schroth Gary P GP Tanay Amos A Hadjur Suzana S
The EMBO journal 20131101 24
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information. Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elements, suggesting that compartmentalization is important for genome function. Here, we show that very specific long-range interactions are anchored by cohesin/CTCF sites, but not cohesin-only or CTCF-o ...[more]