Dataset Information
Transcription profiling time series of the Rattus norvegicus skeletal muscle response to treatment with the corticosteroid methylprednisolone
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Eric Hoffman
PROVIDER: E-GEOD-490 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle.
The Journal of endocrinology 20050101 1
Elevated systemic levels of glucocorticoids are causally related to peripheral insulin resistance. The pharmacological use of synthetic glucocorticoids (corticosteroids) often results in insulin resistance/type II diabetes. Skeletal muscle is responsible for close to 80% of the insulin-induced systemic disposal of glucose and is a major target for glucocorticoid-induced insulin resistance. We used Affymetrix gene chips to profile the dynamic changes in mRNA expression in rat skeletal muscle in r ...[more]
