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Gene expression-based, six individualized outcomes for cancer cells treated by TMEFF2 adenovirus and 2837 genes changes after treatment.

ABSTRACT: The genes expression changes after the adenovirus treatment for 36 hours In this study, the three control groups and three treatment groups were used to acquire expression profiles

ORGANISM(S): Homo sapiens

SUBMITTER: jingyuan fang

PROVIDER: E-GEOD-49049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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TMEFF2 deregulation contributes to gastric carcinogenesis and indicates poor survival outcome.

Sun Tiantian T Du Wan W Xiong Hua H Yu Yanan Y Weng Yurong Y Ren Linlin L Zhao Huijun H Wang Yingchao Y Chen Yingxuan Y Xu Jie J Xiang Yongbing Y Qin Wenxin W Cao Weibiao W Zou Weiping W Chen Haoyan H Hong Jie J Fang Jing-Yuan JY

Clinical cancer research : an official journal of the American Association for Cancer Research 20140701 17

<h4>Purpose</h4>The role and clinical implication of the transmembrane protein with EGF and two follistatin motifs 2 (TMEFF2) in gastric cancer is poorly understood.<h4>Experimental design</h4>Gene expression profile analyses were performed and Gene Set Enrichment Analysis (GSEA) was used to explore its gene signatures. AGS and MKN45 cells were transfected with TMEFF2 or control plasmids and analyzed for gene expression patterns, proliferation, and apoptosis. TMEFF2 expression was knocked down w ...[more]

PMID: 24987055

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