Skin layer-specific transcriptional profiles in normal and recessive yellow (Mc1r/Mc1r) mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Craig April
PROVIDER: E-GEOD-4910 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Skin layer-specific transcriptional profiles in normal and recessive yellow (Mc1re/Mc1re) mice.
April Craig S CS Barsh Gregory S GS
Pigment cell research 20060601 3
The melanocortin 1 receptor (Mc1r) plays a central role in cutaneous biology, but is expressed at very low levels by a small fraction of cells in the skin. In humans, loss-of-function MC1R mutations cause fair skin, freckling, red hair, and increased predisposition to melanoma; in mice, Mc1r loss-of-function is responsible for the recessive yellow mutation, associated with pheomelanic hair and a decreased number of epidermal melanocytes. To better understand how Mc1r signaling affects different ...[more]
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